Mutagenic Impurity Analysis
The BrightSpec Solution
Mutagenic impurities pose a significant challenge for pharamaceutical analytical chemists, given that they are a health risk even at trace levels. Identification and quantitation of these (often unknown) impurities can be an onerous process. MRR provides fingerprint spectra of impurities based on the three-dimensional moments of inertia, and can be identified through comparison to BrightSpec’s spectral library, or even directly to quantum chemical calculations without a reference standard required. BrightSpec has developed a Thermal Evolution sampling method to release all volatile impurities in a solid sample, which delivers structural identification and quantitation in one measurement. This can dramatically speed up the impurities characterization and improve process control.